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水浸拘束下ラット急性胃粘膜病変の形成におけるNitric Oxideの役割についての検討
http://hdl.handle.net/10470/25765
http://hdl.handle.net/10470/25765efb465b0-7516-4833-a58d-c4017eb2ce3a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00006019863.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-08-10 | |||||
| タイトル | ||||||
| タイトル | 水浸拘束下ラット急性胃粘膜病変の形成におけるNitric Oxideの役割についての検討 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 別タイトル | ||||||
| その他のタイトル | Roles of Nitric Oxide in the Formation of Acute Gastric Mucosal Lesions Induced by Water-Immersion-Restraint Stress in Rats | |||||
| 著者名 |
柳沢, 明子
× 柳沢, 明子 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 266129 | |||||
| 姓名 | YANAGISAWA, Akiko | |||||
| 出版者 | ||||||
| 出版者 | 東京女子医科大学学会 | |||||
| 受付日付 | ||||||
| 日付 | 2010-08-10 | |||||
| 日付タイプ | Created | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0040-9022 | |||||
| NCID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00161368 | |||||
| 書誌情報 |
東京女子医科大学雑誌 巻 71, 号 7/8, p. 398-406, 発行日 2001-08-25 |
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| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We examined the level of NOx and the expression of nitric oxide synthase (NOS) to determine the role of nitric oxide (NO) in the formation of acute gastric mucosal lesions induced by waterimmersion-restraint stress (WIRS) in rats. Male Wistar rats were used. Group A was subjected to WIRS (0, 5, 30, 60, 180, 360 min, n=5 per group). Group B consisted of rats given an intraperitoneal injection of L-arginine (100 mg/kg) 30 min before WIRS, which was applied as described for group A. The ulcer index was determined. In addition, the level of NOx in gastric tissue (Griess method), and the expression of NOS (eNOS, nNOS and iNOS) messenger RNA (mRNA) in gastric tissue (RT-PCR) were measured. The localization of NOS was studied by immunostaining. In group A, the ulcer index increased with time after WIRS. There were a decrease in the level of NOx and no increase in the expression of eNOS mRNA. In group B, no lesion was formed after 30 or 60 min, and the level of NOx and the expression of eNOS mRNA increased. There was no expression of iNOS mRNA in either group. No correlation was found between the expression of nNOS mRNA and ulcer index. The localization of eNOS was found in endothelial cells on immunostaining. These results suggest that a decrease in NO level and no increase in the expression of eNOS mRNA are associated with the formation of acute gastric mucosal lesions. Treatment with L-arginine increases the NO level and the expression of eNOS mRNA and inhibits the formation of acute gastric mucosal lesions, suggesting that NO derived from eNOS plays an important part in mucosal protection. | |||||
| 著者所属 | ||||||
| 値 | 東京女子医科大学成人医学センター | |||||
