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The Correlation Between the Intratumoral Thymidylate Synthase Levels and Clinicopathological Factors in Colorectal Cancer Patients
http://hdl.handle.net/10470/25442
http://hdl.handle.net/10470/25442a7adc19f-6f96-4fcc-99b9-f2209566fb31
名前 / ファイル | ライセンス | アクション |
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KJ00006020452.pdf (745.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | The Correlation Between the Intratumoral Thymidylate Synthase Levels and Clinicopathological Factors in Colorectal Cancer Patients | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | 大腸癌における腫瘍組織内Thymidylate Synthaseと臨床病理学的因子の関連についての検討 | |||||
著者名 |
UMEHARA, Arihiro
× UMEHARA, Arihiro× YOSHIMATSU, Kazuhiko× ENDO, Shungo× KATO, Hiroyuki× HAGA, Shunsuke |
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著者別名 | ||||||
姓名 | 梅原, 有弘 | |||||
著者別名 | ||||||
姓名 | 吉松, 和彦 | |||||
著者別名 | ||||||
姓名 | 遠藤, 俊吾 | |||||
著者別名 | ||||||
姓名 | 加藤, 博之 | |||||
著者別名 | ||||||
姓名 | 芳賀, 駿介 | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 70, 号 10/11, p. 621-629, 発行日 2000-11-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Thymidylate synthase (TS)はDNA合成に関わる酵素で,フッ化ピリミジン系抗癌剤の作用にも関与している.そこで大腸癌の腫瘍組織内TS量を測定し,臨床病理学的因子との関連から悪性度の指標としての可能性について検討した.対象は1989~1995年までの大腸癌切除例のうち,癌組織を新鮮凍結しておいた44例である.方法は凍結標本から蛋白を抽出し,一次抗体として抗ヒトrecombinant TSポリクローナル抗体を用いて,Western blot法でTSを検出した.さらに検出されたバンドを画像解析し,positive controlとの比率からTS量を半定量化し,臨床病理学的因子との関連を検討した.臨床病理学的因子のうち,年齢,性別,腫瘍径,組織学的分類,静脈侵襲については,TS量との関連は認められなかった.術前CEA値からは陽性例でTSは低値であり,またリンパ節転移陽性例,肝転移陽性例,リンパ管侵襲が高度な症例でTSは低値であった.Dukes分類からみると進行した症例ほどTSは低値であり,Dukes分類とTSとの間に関連を認めた.さらに対象をTS値から低値群,中間群,高値群の3群に分けると,TS値が低いほど予後は不良で,各群間に差を認めた.以上の結果から,大腸癌における腫瘍組織内TS量は悪性度の指標となると考えられる. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We determined the thymidylate synthase (TS) levels in colorectal cancer tissue specimens and then investigated the potential of using the TS levels as a prognostic factor in colorectal cancer. The subjects consisted of 44 patients with colorectal cancer who had been treated by a resection. The specimens were assayed by Western blotting using anti-human recombinant TS polyclonal antibody. The TS level was then determined semiquantitatively by an image analysis of the obtained, bands. When the TS levels were viewed in the context of clinicopathological factors, low TS levels were seen in patients with positive serum carcinoembryonic antigen, lymph node metastases, liver metastases, and high grade lymphatic invasion. In patients with advanced Dukes stage, the TS levels were also low, thus suggesting that some correlation may exist between the stage and the TS levels. We concluded that the TS levels in colorectal cancer thus predicted the outcome of the disease, and therefore the TS levels may be useful as a prognostic factor. | |||||
著者所属 | ||||||
Department of Surgery, Tokyo Women's Medical University Daini Hospital | ||||||
著者所属 | ||||||
Department of Surgery, Tokyo Women's Medical University Daini Hospital | ||||||
著者所属 | ||||||
Department of Surgery, Tokyo Women's Medical University Daini Hospital | ||||||
著者所属 | ||||||
Department of Surgery, Tokyo Women's Medical University Daini Hospital | ||||||
著者所属 | ||||||
Department of Surgery, Tokyo Women's Medical University Daini Hospital | ||||||
著者所属 | ||||||
東京女子医科大学附属第二病院外科 | ||||||
著者所属 | ||||||
東京女子医科大学附属第二病院外科 | ||||||
著者所属 | ||||||
東京女子医科大学附属第二病院外科 | ||||||
著者所属 | ||||||
東京女子医科大学附属第二病院外科 | ||||||
著者所属 | ||||||
東京女子医科大学附属第二病院外科 |