WEKO3
アイテム
{"_buckets": {"deposit": "95a91891-2526-41c0-9021-33dbc7e65086"}, "_deposit": {"created_by": 3, "id": "16997", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "16997"}, "status": "published"}, "_oai": {"id": "oai:twinkle.repo.nii.ac.jp:00016997", "sets": ["1928"]}, "author_link": ["261276", "261271", "261273", "261274", "261275", "261272", "261270", "261277"], "item_10001_alternative_title_1": {"attribute_name": "別タイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Evaluation of Improvement of Hepatic Fibrosis After Interferon Therapy for Chronic Hepatitis Type C"}]}, "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-05-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "222", "bibliographicPageStart": "215", "bibliographicVolumeNumber": "68", "bibliographic_titles": [{"bibliographic_title": "東京女子医科大学雑誌"}]}]}, "item_10001_creator_2": {"attribute_name": "著者名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "高橋, 春樹"}], "nameIdentifiers": [{"nameIdentifier": "261270", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "富松, 昌彦"}], "nameIdentifiers": [{"nameIdentifier": "261271", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "大川, 真一郎"}], "nameIdentifiers": [{"nameIdentifier": "261272", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "相羽, 元彦"}], "nameIdentifiers": [{"nameIdentifier": "261273", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_date_25": {"attribute_name": "受付日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2010-08-10", "subitem_date_issued_type": "Created"}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We studied the change of hepatic fibrosis after the cessation of interferon (IFN) therapy for chronic hepatitis type C in 46 patients. We stained biopsy specimens by Masson trichrome staining and immunohistochemical staining for type I・III・IV collagens, and classified the cases into 4 stages (F_0~F_3). The effect of IFN was correlated with quantity and genotype of HCV but not with a pathological stage. Hepatic fibrosis improved more significantly in responders than in non-responders in terms of both pathology and fibrogenesis serum markers. We concluded that IFN works indirectly on improvement of fibrosis by way of HCV clearance. Type I collagen was observed only in Glisson sheath. In F_1, but was additionally observed in the expanded fibrotic areas in F_2 and F_3. In improved cases, type III and type IV collagens appeared as pericellular fibrosis and thin septal fibrosis, with type I collagen was also present in the same area. These histological features may show the process of hepatic collagen degeneration.", "subitem_description_type": "Abstract"}]}, "item_10001_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "261274", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "TAKAHASHI, Haruki"}]}, {"nameIdentifiers": [{"nameIdentifier": "261275", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "TOMIMATSU, Masahiko"}]}, {"nameIdentifiers": [{"nameIdentifier": "261276", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "OHKAWA, Shin-ichiro"}]}, {"nameIdentifiers": [{"nameIdentifier": "261277", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "AIBA, Motohiko"}]}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "東京女子医科大学学会"}]}, "item_10001_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00161368", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0040-9022", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_35": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "東京女子医科大学附属第二病院内科"}, {"subitem_text_value": "東京女子医科大学附属第二病院内科"}, {"subitem_text_value": "東京女子医科大学附属第二病院内科"}, {"subitem_text_value": "東京女子医科大学附属第二病院病理科"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-03-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00006024535.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "KJ00006024535.pdf", "url": "https://twinkle.repo.nii.ac.jp/record/16997/files/KJ00006024535.pdf"}, "version_id": "11d7647d-ec0e-4568-9be6-e44fc9578b16"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "C型慢性肝炎のインターフェロン治療後の線維化の改善に関する検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "C型慢性肝炎のインターフェロン治療後の線維化の改善に関する検討"}]}, "item_type_id": "10001", "owner": "3", "path": ["1928"], "permalink_uri": "http://hdl.handle.net/10470/24296", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-08-10"}, "publish_date": "2010-08-10", "publish_status": "0", "recid": "16997", "relation": {}, "relation_version_is_last": true, "title": ["C型慢性肝炎のインターフェロン治療後の線維化の改善に関する検討"], "weko_shared_id": -1}
C型慢性肝炎のインターフェロン治療後の線維化の改善に関する検討
http://hdl.handle.net/10470/24296
http://hdl.handle.net/10470/24296f745bc6c-3c3f-410d-8b27-91b256d90826
名前 / ファイル | ライセンス | アクション |
---|---|---|
KJ00006024535.pdf (2.8 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | C型慢性肝炎のインターフェロン治療後の線維化の改善に関する検討 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Evaluation of Improvement of Hepatic Fibrosis After Interferon Therapy for Chronic Hepatitis Type C | |||||
著者名 |
高橋, 春樹
× 高橋, 春樹× 富松, 昌彦× 大川, 真一郎× 相羽, 元彦 |
|||||
著者別名 | ||||||
姓名 | TAKAHASHI, Haruki | |||||
著者別名 | ||||||
姓名 | TOMIMATSU, Masahiko | |||||
著者別名 | ||||||
姓名 | OHKAWA, Shin-ichiro | |||||
著者別名 | ||||||
姓名 | AIBA, Motohiko | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 68, 号 5, p. 215-222, 発行日 1998-05-25 |
|||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We studied the change of hepatic fibrosis after the cessation of interferon (IFN) therapy for chronic hepatitis type C in 46 patients. We stained biopsy specimens by Masson trichrome staining and immunohistochemical staining for type I・III・IV collagens, and classified the cases into 4 stages (F_0~F_3). The effect of IFN was correlated with quantity and genotype of HCV but not with a pathological stage. Hepatic fibrosis improved more significantly in responders than in non-responders in terms of both pathology and fibrogenesis serum markers. We concluded that IFN works indirectly on improvement of fibrosis by way of HCV clearance. Type I collagen was observed only in Glisson sheath. In F_1, but was additionally observed in the expanded fibrotic areas in F_2 and F_3. In improved cases, type III and type IV collagens appeared as pericellular fibrosis and thin septal fibrosis, with type I collagen was also present in the same area. These histological features may show the process of hepatic collagen degeneration. | |||||
著者所属 | ||||||
東京女子医科大学附属第二病院内科 | ||||||
著者所属 | ||||||
東京女子医科大学附属第二病院内科 | ||||||
著者所属 | ||||||
東京女子医科大学附属第二病院内科 | ||||||
著者所属 | ||||||
東京女子医科大学附属第二病院病理科 |