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多臓器障害(MODS)症例における血管新生因子の経時的変化と予後についての検討
http://hdl.handle.net/10470/24288
http://hdl.handle.net/10470/24288ca9128a0-7340-43f3-bb4b-bf83d6fab1f0
名前 / ファイル | ライセンス | アクション |
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KJ00006024539.pdf (791.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 多臓器障害(MODS)症例における血管新生因子の経時的変化と予後についての検討 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Relationships Between Angiogenesis and Prognosis of Multiple Organ Dysfunction Syndrome | |||||
著者名 |
矢口, 有乃
× 矢口, 有乃× 石川, 雅健× 曽我, 幸弘× 武田, 宗和× 鈴木, 忠 |
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著者別名 | ||||||
姓名 | YAGUCHI, Arino | |||||
著者別名 | ||||||
姓名 | ISHIKAWA, Masatake | |||||
著者別名 | ||||||
姓名 | SOGA, Yukihiro | |||||
著者別名 | ||||||
姓名 | TAKEDA, Munekazu | |||||
著者別名 | ||||||
姓名 | SUZUKI, Tadashi | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 68, 号 5, p. 249-257, 発行日 1998-05-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Multiple organ dysfunction syndrome (MODS) still has a poor prognosis and its mortality is high. We have considered the function of how vascular endothelial cells influence the pathophysiology and prognosis of MODS and hypothesized there are similar relationships between prognosis and angiogenesis after endothelial cell injuries. So we investegated the factors of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) as induction factors of angiogenesis, and platelet factor 4 (PF-4) as a suppression factor. We studied the angiogenesis and endothelial cell injuries in 21 MODS patients. Since their admission to the intensive care unit, we have surveyed the blood concentrations of VEGF, PDGF, PF-4 and compared the survivors with the dead. Among 21 MODS, in 12 survivors the blood level of VEFG and PDGF elevated after their injuries, and PF-4 decreased; however, after the patients were cured VEGF and PDGF decreased whereas PF-4 increased. The other 9 patients died while VEGF, PDGF and PF-4 did not significantly change. Therefore, the induction and suppression of angiogenesis were controlled appropriately in the survivors but were not in the dead. We conclude that if there is appropriate angiogenesis, the prognosis will be good; but if angiogenesis is poor, the prognosis will be bad. We must recognize and include "vascular (endothelial cell)" as one of the organs of MODS. | |||||
著者所属 | ||||||
東京女子医科大学救急医学教室 | ||||||
著者所属 | ||||||
東京女子医科大学救急医学教室 | ||||||
著者所属 | ||||||
東京女子医科大学救急医学教室 | ||||||
著者所属 | ||||||
東京女子医科大学救急医学教室 | ||||||
著者所属 | ||||||
東京女子医科大学救急医学教室 |