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胎盤形成過程における線溶系因子の検討
http://hdl.handle.net/10470/24168
http://hdl.handle.net/10470/2416843ed5c54-7100-42b3-ab30-889ac73117a7
名前 / ファイル | ライセンス | アクション |
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KJ00006025296.pdf (624.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 胎盤形成過程における線溶系因子の検討 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | The Study of Fibrinolytic Factors in the Process of Placentation | |||||
著者名 |
平野, 郁子
× 平野, 郁子× 中林, 正雄× 矢島, 正純× 武田, 佳彦 |
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著者別名 | ||||||
姓名 | HIRANO, Ikuko | |||||
著者別名 | ||||||
姓名 | NAKABAYASHI, Masao | |||||
著者別名 | ||||||
姓名 | YAJIMA, Masazumi | |||||
著者別名 | ||||||
姓名 | TAKEDA, Yoshihiko | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 67, 号 12, p. 1078-1083, 発行日 1997-12-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It is suggested that the processes of implantation and placentation are both dependent on the invasion to the decidual tissue by trophoblasts, and fibrinolytic factors are involved with the regulation mechanisms of the invasion and placentation. We studied the locarization of fibrinolytic factors (urokinase type plasminogen activator: uPA and tissue type plasminogen activator: tPA), uPA receptor (uPAR) and plasminogen activator inhibitor-1 (PAI-1). The levels of uPA in decidual and villous extracts were almost same and showed no change throughout the pregnancy period. While the levels of tPA, PAI-1 and uPAR in decidual extracts of first and second-trimester placentae are higher than that of third trimester placentae. The levels of tPA, PAI-1 and uPAR in villous extracts were low and showed no change throughout the pregnancy period. Immunohistochemical method was applied to elucidate the localization of uPA and uPAR. uPA was recognized in the cytotrophoblast cells of the 1st and 2nd trimester placenta and not recognized in the syncytiotrophoblast cells. uPAR were also recognized in the cytotrophoblast cells and extravillous trophoblast cells of the 1st and 2nd trimester placentae. These results suggest that expression of uPA and uPAR on trophoblast may play an important role in the regulation mechanisms of the invasion and implantation of placenta. | |||||
著者所属 | ||||||
東京女子医科大学産婦人科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学産婦人科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学産婦人科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学産婦人科学教室 |