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子宮体癌におけるエストロゲンレセプターの発現と抗Ki-67抗体を用いた細胞増殖能についての免疫組織化学的検討
http://hdl.handle.net/10470/24164
http://hdl.handle.net/10470/24164c4a22996-07dd-4d1b-8a0b-91a56fc984a1
名前 / ファイル | ライセンス | アクション |
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KJ00006025293.pdf (977.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 子宮体癌におけるエストロゲンレセプターの発現と抗Ki-67抗体を用いた細胞増殖能についての免疫組織化学的検討 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Immunohistochemical Study of the Estrogen Receptor and Ki-67 Expression in Endometrial Carcinoma | |||||
著者名 |
菊地, 愛子
× 菊地, 愛子 |
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著者別名 | ||||||
姓名 | KIKUCHI, Aiko | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 67, 号 12, p. 1054-1062, 発行日 1997-12-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the tumors of fifty-eight patients with endometrial carcinoma by immunohistochemical analysis of estrogen receptor (ER) expression and Ki-67 labeling index (L.I.). In twenty-four patients we also performed a biochemical analysis of ER. The results were as follows. 1) There was a good correlation between the immunohistochemical categories and biochemical levels of ER. 2) The presence of ER was significantly (p <0.05) associated with surgical stage, but was not related to histologic differentiation. 3) In the ER-negative group, Ki-67 L.I. was significantly (p <0.05) associated with surgical stage, histologic differentiation, lymph-node metastasis, ductal permeation and recurrence, Ki-67 may become a prognostic marker in this group of patients. 4) In the premenopausal patients who had ER, the level of Ki-67 was significantly higher (p <0.01) than the ER-negative premenopausal patients. Our results suggest that the proliferative effect of the endogenous estrogen on endometrial carcinoma affects the Ki-67 levels in the ER-positive group, where as some extra-estrogenic factor such as an oncogene may affect the elevated Ki-67 levels in the ER-negative group. Immunohistochemical analysis of ER status with Ki-67 L.I. is not only simple and practical, but also predicts the degree of malignancy. | |||||
著者所属 | ||||||
東京女子医科大学産婦人科学教室 |