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ベーチェット病における好中球のインターロイキン-8産生能とFK506による産生抑制
http://hdl.handle.net/10470/24163
http://hdl.handle.net/10470/241638c27aafc-dbae-41c7-be4f-408944e3d19b
名前 / ファイル | ライセンス | アクション |
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KJ00006025291.pdf (721.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | ベーチェット病における好中球のインターロイキン-8産生能とFK506による産生抑制 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Interleukin-8 Production of Neutrophils and Inhibitory Effects of FK506 in Behcet's Disease | |||||
著者名 |
八木, 郁子
× 八木, 郁子× 小暮, 美津子× 西川, 恵× 相川, 英三 |
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著者別名 | ||||||
姓名 | YAGI, Ikuko | |||||
著者別名 | ||||||
姓名 | KOGURE, Mitsuko | |||||
著者別名 | ||||||
姓名 | NISHIKAWA, Megumi | |||||
著者別名 | ||||||
姓名 | AIKAWA, Eizo | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 67, 号 12, p. 1041-1048, 発行日 1997-12-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | While the etiology of Behcet's disease is still unknown, it is believed that functional abnormalities of neutrophils, such as increases in the migration and production of active oxygen, are intimately involved in the pathogenesis of the disease. This study was undertaken to examine the interleukin-8 (IL-8) production of peripheral neutrophils, focusing on the fact that the IL-8 activates neutrophil migration and enhances their function, and to examine the inhibitory effects of FK506 (an immunosuppressive agent) on neutrophil production of IL-8. Peripheral neutrophil specimens were collected from patients with Behcet's disease and healthy persons, and divided into a group stimulated by lipopolysaccharide (LPS) (LPS-stimulated group) and a group not stimulated by it (non-stimulated group). IL-8 secretion was measured in the both groups to assess the expression of IL-8 mRNA. In addition, FK506 was added to the LPS-stimulated culture to measure IL-8 secretion by neutrophils. The results showed increased neutrophil production of IL-8 in the Behcet's disease group and expression of IL-8 mRNA even in the non-stimulated group. The IL-8 production was shown to be inhibited by FK506. These findings suggest that Behcet's disease is associated with in vivo priming of peripheral neutrophils, implying that IL-8 produced by neutrophils plays a role in the pathogenesis of Behcet's disease. In addition, FK506 may have an inhibitory effection neutrophil IL-8 production as a mechanism in Behcet's disease. | |||||
著者所属 | ||||||
東京女子医科大学眼科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学眼科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学解剖学・発生生物学教室 | ||||||
著者所属 | ||||||
東京女子医科大学解剖学・発生生物学教室 |