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ベーチェット病患者の虹彩における補体制御因子の免疫組織学的検討
http://hdl.handle.net/10470/24152
http://hdl.handle.net/10470/241524683e2b7-f8b1-48ce-8266-11dfe7e1fbbf
名前 / ファイル | ライセンス | アクション |
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KJ00006025248.pdf (708.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | ベーチェット病患者の虹彩における補体制御因子の免疫組織学的検討 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Immunofluorescence Study of Complement Regulatory Proteins in Irises from Patients with Behcet's Disease | |||||
著者名 |
呉, 朋子
× 呉, 朋子× 小暮, 美津子× 陳, 麗理× 西川, 恵× 相川, 英三 |
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著者別名 | ||||||
姓名 | KURE, Tomoko | |||||
著者別名 | ||||||
姓名 | KOGURE, Mitsuko | |||||
著者別名 | ||||||
姓名 | CHEN, Li-Li | |||||
著者別名 | ||||||
姓名 | NISHIKAWA, Megumi | |||||
著者別名 | ||||||
姓名 | AIKAWA, Eizo | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 67, 号 11, p. 937-943, 発行日 1997-11-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although it's known that complement regulatory proteins, which protect self-cells from activation of the complement, spread widely in a living body, we haven't had any reports about the existence of them in the human iris yet. In this study, we used an Immunofluorescence technique and investigated the expression of C3bC4b receptor (CR1), membrane cofactor protein (MCP) and decay accelerating factor (DAF), which inhibit activation of C3, and homologous restriction factor 20 (HRF20), which inhibits activation of C9, in irises from 7 patients with Behcet's disease and 7 patients with glaucoma but without uveitis as controls. CR1, MCP and DAF weren't observed in any patients. HRF20 was expressed on endothelial cells of vessels, iris stroma and iris pigment epithelium in all patients. Comparing the patients and the controls, revealed no significant differences. From these results, we propose as for activation of the complement system in the human iris, acceleration of vascular permeability and chemotactic activity of polymorphonuclear leucocytes, which are caused by activation of C3, occur easily and that cytolysis, which is caused by activation of C9, hardly occurs. We also propose the result that the less existence of complement regulatory proteins in the patients concerns the pathogenesis of the disease. | |||||
著者所属 | ||||||
東京女子医科大学眼科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学眼科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学眼科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学解剖学・発生生物学教室 | ||||||
著者所属 | ||||||
東京女子医科大学解剖学・発生生物学教室 |