WEKO3
アイテム
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It is not yet clear, whether the NDP kinase is associated with metastatic potential in gallbladder carcinomas that has invaded the subserosal layer (Gb-ssca). We therefore immunohistochemically examined the expression of NDP kinase-A in Gb-ssca in order to clarify associations between its expression and the clinical features of the disease. Of the 40 patients tested, 25 (63%; Group B) showed strong immunoreactinity for NDP kinase-A in most carcinoma cells within the subserosal tumor tissue, while 15 (37%; Group A) contained few or no NDP kinase-A-positive carcinoma cells. In addition, carcinoma cells in the mucosa showed lower NDP kinase-A immunoreactively than those in the subserosa in 11 cases (27%). In Gb-ssca, high levels of NDP kinase-A expression were associated with positive status of distant lymph node (p \u003c0.05) and poorer prognosis (p \u003c0.05). These findings are consistent with the view that higher levels of NDP kinase expression are associated with carcinoma progression in Gb-ssca and that it may be a prognosis-regulating factor in Gb-ssca. 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IMMUNOHISTOCHEMICAL EXPRESSION OF nm23 GENE PRODUCT CORRELATES WITH LYMPH NODE METASTASIS AND ADVERSE PROGNOSIS IN GALLBLADDER CARCINOMAS INVADING THE SUBSEROSAL LAYER
http://hdl.handle.net/10470/23851
http://hdl.handle.net/10470/238511581034e-af9a-465b-9824-e94e880856d4
名前 / ファイル | ライセンス | アクション |
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KJ00006025078.pdf (989.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | IMMUNOHISTOCHEMICAL EXPRESSION OF nm23 GENE PRODUCT CORRELATES WITH LYMPH NODE METASTASIS AND ADVERSE PROGNOSIS IN GALLBLADDER CARCINOMAS INVADING THE SUBSEROSAL LAYER | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | 漿膜下層浸潤胆嚢癌におけるnm23遺伝子翻訳産物の免疫組織化学的発現率とリンパ節転移および予後との関連 | |||||
著者名 |
ZHOU, Zheng
× ZHOU, Zheng× YOSHIKAWA, Tatsuya× ARAIDA, Tatsuo× AZUMA, Tsukasa× TAKASAKI, Ken |
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著者別名 | ||||||
姓名 | 周, 正 | |||||
著者別名 | ||||||
姓名 | 吉川, 達也 | |||||
著者別名 | ||||||
姓名 | 新井田, 達雄 | |||||
著者別名 | ||||||
姓名 | 吾妻, 司 | |||||
著者別名 | ||||||
姓名 | 高崎, 健 | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 67, 号 6, p. 420-425, 発行日 1997-06-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 乳癌ほかいくつかの癌で癌組織内のnm23遺伝子翻訳産物/NDP kinaseの発現の多寡が転移および予後に深く関与していることが明らかにされ,予後因子としての有用性が期待されている.しかし漿膜下層浸潤胆嚢癌における検討は文献的にはまだ認められない.今回われわれは胆嚢癌手術材料について免疫組織化学的方法を用い,NDP kinase-Aと漿膜下層浸潤胆嚢癌との関連を検討した.漿膜下層浸潤胆嚢癌40例を対象とし癌細胞のNDP kinase-A発現50%未満(A群)と50%以上(B群)に分けて検討すると,2群以上の遠位リンパ節転移率はB群に有意に高く,予後も有意に不良であった.漿膜下層浸潤胆嚢癌においてはNDPkinase-A発現はリンパ節転移および予後とは有意な関連があり,転移予後の予測因子として有用性が示唆された.また11症例(27%)では粘膜内癌,筋層浸潤癌の部より漿膜下層浸潤癌の部においてNDP kinase-A染色程度は強く認められ,NDP kinase-Aは胆嚢癌の進展に関連することが示唆された. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Levels of nm23 gene product/NDP kinase expression have been demonstrated to be inversely correlated with metastatic potential in some tumors, but not in others. It is not yet clear, whether the NDP kinase is associated with metastatic potential in gallbladder carcinomas that has invaded the subserosal layer (Gb-ssca). We therefore immunohistochemically examined the expression of NDP kinase-A in Gb-ssca in order to clarify associations between its expression and the clinical features of the disease. Of the 40 patients tested, 25 (63%; Group B) showed strong immunoreactinity for NDP kinase-A in most carcinoma cells within the subserosal tumor tissue, while 15 (37%; Group A) contained few or no NDP kinase-A-positive carcinoma cells. In addition, carcinoma cells in the mucosa showed lower NDP kinase-A immunoreactively than those in the subserosa in 11 cases (27%). In Gb-ssca, high levels of NDP kinase-A expression were associated with positive status of distant lymph node (p <0.05) and poorer prognosis (p <0.05). These findings are consistent with the view that higher levels of NDP kinase expression are associated with carcinoma progression in Gb-ssca and that it may be a prognosis-regulating factor in Gb-ssca. It is also suggested that expression of NDP kinase-A in Gb-ssca, may not only have implications for metastasis but that it may also play a part in local invasion. | |||||
著者所属 | ||||||
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical College | ||||||
著者所属 | ||||||
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical College | ||||||
著者所属 | ||||||
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical College | ||||||
著者所属 | ||||||
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical College | ||||||
著者所属 | ||||||
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical College | ||||||
著者所属 | ||||||
東京女子医科大学消化器病センター外科 | ||||||
著者所属 | ||||||
東京女子医科大学消化器病センター外科 | ||||||
著者所属 | ||||||
東京女子医科大学消化器病センター外科 | ||||||
著者所属 | ||||||
東京女子医科大学消化器病センター外科 | ||||||
著者所属 | ||||||
東京女子医科大学消化器病センター外科 |