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C型慢性肝炎における肝組織内HCV-RNA量とインターフェロン治療効果について
http://hdl.handle.net/10470/23838
http://hdl.handle.net/10470/23838f8f6b286-fe79-4a7d-9fd1-974c3d150d97
名前 / ファイル | ライセンス | アクション |
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KJ00006025077.pdf (377.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | C型慢性肝炎における肝組織内HCV-RNA量とインターフェロン治療効果について | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Relation between HCV-RNA Level in Liver Tissue and the Response to Interferon Therapy in Patients with Chronic Hepatitis C | |||||
著者名 |
中島, 博子
× 中島, 博子× 富松, 昌彦× 玉井, 紀男× 伊賀, 大二郎× 遠藤, 仁× 高橋, 春樹× 岡野, 晃× 森, 治樹× 久富, 寿 |
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著者別名 | ||||||
姓名 | NAKAJIMA, Hiroko | |||||
著者別名 | ||||||
姓名 | TOMIMATSU, Masahiko | |||||
著者別名 | ||||||
姓名 | TAMAI, Norio | |||||
著者別名 | ||||||
姓名 | IGA, Daijiro | |||||
著者別名 | ||||||
姓名 | ENDO, Hitoshi | |||||
著者別名 | ||||||
姓名 | TAKAHASHI, Haruki | |||||
著者別名 | ||||||
姓名 | OKANO, Akira | |||||
著者別名 | ||||||
姓名 | MORI, Haruki | |||||
著者別名 | ||||||
姓名 | HISATOMI, Hisashi | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 67, 号 6, p. 414-419, 発行日 1997-06-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Liver tissue and serum samples were obtained from 23 patients with chronic hepatitis C, and HCV-RNA levels of those samples were quantitated using RT-competitive PCR assay. We investigated the correlations between the hepatic HCV-RNA level, HCV genotype, and the effects of interferon (IFN) therapy. Complete responders (CR), in whom HCV-RNA was cleared from serum more than six months after the end of IFN treatment, numbered 11 cases (47.8%). Non responders (NR), in whom serum HCV-RNA was detected after treatment numbered 12 cases (52.2%). Before IFN treatment, there was a strong correlation between hepatic and serum HCV-RNA levels (r=0.72, p<0.0001). The HCV-RNA level in liver tissue was significantly higher, i.e., about 10^3 times, than it was in serum. HCV genotypes II and IV showed higher HCV-RNA levels than genotype III in both liver tissue and serum. HCV-RNA levels in liver tissue tended to be lower in CR than in NR. These observations suggest that the effect of IFN can be adequately predicted by looking at only HCV-RNA level and genotype in serum. | |||||
著者所属 | ||||||
東京女子医科大学第二病院内科II | ||||||
著者所属 | ||||||
東京女子医科大学第二病院内科II | ||||||
著者所属 | ||||||
東京女子医科大学第二病院内科II | ||||||
著者所属 | ||||||
東京女子医科大学第二病院内科II | ||||||
著者所属 | ||||||
東京女子医科大学第二病院内科II | ||||||
著者所属 | ||||||
東京女子医科大学第二病院内科II | ||||||
著者所属 | ||||||
東京女子医科大学第二病院内科II | ||||||
著者所属 | ||||||
東京女子医科大学第二病院内科II | ||||||
著者所属 | ||||||
(株)エスアールエル遺伝子・染色体解析センター |