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IGF-II産生腫瘍中のIGF-IIの血中存在様式に関する検討
http://hdl.handle.net/10470/23719
http://hdl.handle.net/10470/23719bf00b0f3-9c3f-438b-bc60-4e3ba687669a
名前 / ファイル | ライセンス | アクション |
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KJ00006024942.pdf (569.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | IGF-II産生腫瘍中のIGF-IIの血中存在様式に関する検討 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Circulating Forms of IGF-II in IGF-II Producing Tumor | |||||
著者名 |
福田, いずみ
× 福田, いずみ× 肥塚, 直美× 大久保, 由美子× 安本, 久美子× 高野, 加寿恵× 出村, 博 |
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著者別名 | ||||||
姓名 | FUKUDA, Izumi | |||||
著者別名 | ||||||
姓名 | HIZUKA, Naomi | |||||
著者別名 | ||||||
姓名 | OKUBO, Yumiko | |||||
著者別名 | ||||||
姓名 | YASUMOTO, Kumiko | |||||
著者別名 | ||||||
姓名 | TAKANO, Kazue | |||||
著者別名 | ||||||
姓名 | DEMURA, Hiroshi | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 67, 号 1/2, p. 1-6, 発行日 1997-02-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Extrapancreatic tumor associated with hypoglycemia (non-islet-cell tumor hypoglycemia: NICTH) is one of major causes of fasting hypoglycemia. In some patients with NICTH, insulin-like growth factor II (IGF-II) produced by tumors is thought to be a hypoglycemic agent. However, the mechanisms of hypoglycemia is still unknown, because serum IGF-II levels are not always elevated in patients with NICTH. One of the possible mechanisms of hypoglycemia is an increase of free form of IGF-II in serum. In the present study, we investigated whether free form of IGF-II in serum is increased using gel filtration method. Furthermore, heterogeneity of IGF-II was studied by Western immunoblot. When normal serum was gel filtered at pH 7.4, 150 kDa and 40 kDa complexes of IGF-II with IGF binding proteins (IGFBPs) were found. In patients with NICTH, the 150 kDa and 40 kDa complexes were not found but a peak of IGF-II with IGFBPs eluted as 60~80 kDa was found. In this fraction, four IGFBPs (IGFBP-1, -2, -3, -4) were found by Western ligand blot. A small peak of IGF-II eluted in approximately 17 kDa was found in sera from six of ten patients with NICTH. In the peak fraction (17 kDa), IGFBPs were not found by Western ligand blot and big form of IGF-II (11-18 kDa) was observed by Western immunoblot. These data indicated that free form of big IGF-II was increased in sera from these patients. Furthermore, IGF-II eluted as 60-80 kDa complex in patients with NICTH was mainly big form of IGF-II. These data suggest that big IGF-II binds IGFBPs, and the big IGF-II with IGFBP-3 dose not bind acid labile subunit, resulting in decreased 150 kDa complex formation. An increase of free form of big IGF-II and decreased 150 kDa complex formation in sera from patients with NICTH, might be related to hypoglycemia. | |||||
著者所属 | ||||||
東京女子医科大学第二内科学 | ||||||
著者所属 | ||||||
東京女子医科大学第二内科学 | ||||||
著者所属 | ||||||
東京女子医科大学第二内科学 | ||||||
著者所属 | ||||||
東京女子医科大学第二内科学 | ||||||
著者所属 | ||||||
東京女子医科大学第二内科学 | ||||||
著者所属 | ||||||
東京女子医科大学第二内科学 |