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同種サル腎移植におけるmixed chimerismによる免疫寛容導入と全身照射の至適条件に関する検討
http://hdl.handle.net/10470/23697
http://hdl.handle.net/10470/23697f8de7dc0-78a2-413f-a3ee-c56b48958ca5
名前 / ファイル | ライセンス | アクション |
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KJ00006025939.pdf (692.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 同種サル腎移植におけるmixed chimerismによる免疫寛容導入と全身照射の至適条件に関する検討 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Optimized Total Body Irradiation for Induction of Renal Allograft Tolerance Through Mixed Chimerism in Cynomolgus Monkeys | |||||
著者名 |
君川, 正昭
× 君川, 正昭× 河合, 達郎× 太田, 和夫 |
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著者別名 | ||||||
姓名 | KIMIKAWA, Masaaki | |||||
著者別名 | ||||||
姓名 | KAWAI, Tatsuo | |||||
著者別名 | ||||||
姓名 | OTA, Kazuo | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 66, 号 12, p. 1151-1159, 発行日 1996-12-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously demonstrated that a nonmyeloablative preparative regimen can induce mixed chimerism and renal allograft tolerance between MHC-disparate non-human primates. The basic regimen includes anti-thymocyte globulin (ATG), total body irradiation (TBI, 300 cGy), thymic irradiation (TI, 700 cGy), splenectomy, donor bone marrow (DBM) infusion, and posttransplant cyclosporine therapy (CYA, discontinued after 4 weeks). To evaluate the importance and to minimize the toxicity of irradiation, kidney allografts were transplanted with various manipulations of the irradiation protocol. Monkeys treated with the basic protocol without TBI and TI did not develop chimerism or long-term allograft survival. In monkeys treated with the full protocol, all six monkeys treated with two fractionated dose of 150 cGy developed chimerism and five monkeys appeared tolerant. In contrast, only two of the four monkeys treated with fractionated doses of 125 cGy developed chimerism and only one monkey survived long term. The degree of lymphocyte depletion in all recipients was proportional to the TBI dose. The fractionated TBI regimen of 150 cGy appears to be the most consistently effective regimen for establishing donor bone marrow cell engraftment and allograft tolerance. | |||||
著者所属 | ||||||
東京女子医科大学第三外科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学第三外科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学第三外科学教室 |