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We investigated the effect of pregnancy on serum proinsulin levels and the proinsulin/insulin ratio (PI/IRI) during an oral glucose tolerance test in pregnant women. Forty-six pregnant women with normal glucose tolerance (NGT), 60 pregnant women with borderline glucose intolerance (BGI), and 10 nonpregnant healthy controls were examined by 75g-oral glucose tolerance test (OGTT). Serum proinsulin was measured by radioimmunoassay using specific antiserum for human proinsulin. Fasting proinsulin levels in nonpregnant controls, NGT in early gestational period, NGT in late gestational, BGI in early gestational, and BGI in lategestational were 5.2 ± 1.2, 6.1 ± 5.9, 8.9 ± 4.5, 8.6 ± 5.5 and 10.9 ± 4.4 pmol/l (mean ± SD), respectively. Fasting PI/IRI ratios in these groups were 0.12 ± 0.04,0.12 ± 0.09,0.19 ± 0.10,0.19 ± 0.13 and 0.27 ± 0.14,respectively.InbothNGTandBGI, fasting proinsulin levels and the PI/IRI ratio in late gestational period were significantly higher than those in the early period. In 27 cases with BGI. OGTT was repeated in the late gestational period. Amelioration of glucose tolerance was observed in 6 cases (group A), but not in 21 cases (group B). Summed values of the serum PI/IRI ratio (2PI/2IRI) during OGTT in early gestationalperiodingroupAwas lowerthaningroup B (0.08 + 0.02 vs 0.15 ± 0.07,p\u003c0.05). 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妊婦における血中プロインスリン分泌動態
http://hdl.handle.net/10470/23624
http://hdl.handle.net/10470/236246d5abdc7-12db-4134-90fd-81832ef32adc
名前 / ファイル | ライセンス | アクション |
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KJ00006025849.pdf (718.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-08-10 | |||||
タイトル | ||||||
タイトル | 妊婦における血中プロインスリン分泌動態 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
別タイトル | ||||||
その他のタイトル | Proinsulin Secretion in Pregnant Women | |||||
著者名 |
金室, 麗子
× 金室, 麗子× 岩本, 安彦× 柳澤, 慶香× 長嶋, たまき× 鈴木, 奈津子× 佐中, 真由実× 大森, 安恵 |
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著者別名 | ||||||
姓名 | KANAMURO, Reiko | |||||
著者別名 | ||||||
姓名 | IWAMOTO, Yasuhiko | |||||
著者別名 | ||||||
姓名 | YANAGISAWA, Keiko | |||||
著者別名 | ||||||
姓名 | NAGASHIMA, Tamaki | |||||
著者別名 | ||||||
姓名 | SUZUKI, Natsuko | |||||
著者別名 | ||||||
姓名 | SANAKA, Mayumi | |||||
著者別名 | ||||||
姓名 | OMORI, Yasue | |||||
出版者 | ||||||
出版者 | 東京女子医科大学学会 | |||||
受付日付 | ||||||
日付 | 2010-08-10 | |||||
日付タイプ | Created | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0040-9022 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00161368 | |||||
書誌情報 |
東京女子医科大学雑誌 巻 66, 号 9/10, p. 795-803, 発行日 1996-10-25 |
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著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Serum proinsulin is disproportionately elevated both at fasting and after an oral glucose load in non-insulin dependent diabetes mellitus. We investigated the effect of pregnancy on serum proinsulin levels and the proinsulin/insulin ratio (PI/IRI) during an oral glucose tolerance test in pregnant women. Forty-six pregnant women with normal glucose tolerance (NGT), 60 pregnant women with borderline glucose intolerance (BGI), and 10 nonpregnant healthy controls were examined by 75g-oral glucose tolerance test (OGTT). Serum proinsulin was measured by radioimmunoassay using specific antiserum for human proinsulin. Fasting proinsulin levels in nonpregnant controls, NGT in early gestational period, NGT in late gestational, BGI in early gestational, and BGI in lategestational were 5.2 ± 1.2, 6.1 ± 5.9, 8.9 ± 4.5, 8.6 ± 5.5 and 10.9 ± 4.4 pmol/l (mean ± SD), respectively. Fasting PI/IRI ratios in these groups were 0.12 ± 0.04,0.12 ± 0.09,0.19 ± 0.10,0.19 ± 0.13 and 0.27 ± 0.14,respectively.InbothNGTandBGI, fasting proinsulin levels and the PI/IRI ratio in late gestational period were significantly higher than those in the early period. In 27 cases with BGI. OGTT was repeated in the late gestational period. Amelioration of glucose tolerance was observed in 6 cases (group A), but not in 21 cases (group B). Summed values of the serum PI/IRI ratio (2PI/2IRI) during OGTT in early gestationalperiodingroupAwas lowerthaningroup B (0.08 + 0.02 vs 0.15 ± 0.07,p<0.05). The results suggest that serum PI/IRI increases during pregnancy and that serum PI/IRI in early gestational period in BGI case serve as a predictor of glucose tolerance in late gestational period. | |||||
著者所属 | ||||||
東京女子医科大学第三内科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学第三内科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学第三内科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学第三内科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学第三内科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学第三内科学教室 | ||||||
著者所属 | ||||||
東京女子医科大学第三内科学教室 |